![]() Acid–base status, renal function, the kinetics of fomepizole, and ethylene glycol metabolism were assessed at predetermined intervals. Treatment was continued until plasma ethylene glycol concentrations were less than 20 mg per deciliter. Patients who met specific criteria also underwent hemodialysis. We administered intravenous fomepizole to 19 patients with ethylene glycol poisoning (plasma ethylene glycol concentration, ≥20 mg per deciliter ). We studied the efficacy of fomepizole, a new inhibitor of alcohol dehydrogenase, in the treatment of ethylene glycol poisoning. The standard treatment is inhibition of alcohol dehydrogenase with ethanol, given in intoxicating doses, and adjunctive hemodialysis. The most trusted, influential source of new medical knowledge and clinical best practices in the world.Įthylene glycol poisoning causes metabolic acidosis and renal failure and may cause death. Information and tools for librarians about site license offerings. Valuable tools for building a rewarding career in health care. The authorized source of trusted medical research and education for the Chinese-language medical community. The most advanced way to teach, practice, and assess clinical reasoning skills. Information, resources, and support needed to approach rotations - and life as a resident. The most effective and engaging way for clinicians to learn, improve their practice, and prepare for board exams. NEW! Peer-reviewed journal featuring in-depth articles to accelerate the transformation of health care delivery.Ĭoncise summaries and expert physician commentary that busy clinicians need to enhance patient care. ![]() NEW! A digital journal for innovative original research and fresh, bold ideas in clinical trial design and clinical decision-making.
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